Associations between hippocampal subfield volume and cognitive performance

Background It is well demonstrated that hippocampal atrophy associated with cognitive impairment. Existing studies have smaller volumes dementia, and volume reduction has been established as a biomarker for the conversion of mild impairment to Alzheimer’s Disease. Although some examined correlations between subfield domains such memory, further research needed clarify associations each various domains. So far few conducted among Asian populations. A more specific understanding these relationships crucial given functional histological differences in subfields their distinct patterns atrophy, which imply may affect cognition differentially. This study aimed investigate 12 on performance Singaporean sample. Method 448 patients at memory clinic Singapore (97 no impairment, 177 CIND, 174 dementia) underwent magnetic resonance imaging (MRI) neuropsychological assessment. MRI was processed through free surfer (v.6.1) extract subfields—the tail, subiculum, presubiculum, parasubiculum, CA1, CA3, CA4, fimbria, fissure, molecular layer, granule cell layers dentate gyrus (GCMLDG), hippocampus-amygdala transition area (HATA). Cognition assessed using NINDS–Canadian Stroke Network harmonization battery. Result Global GCMLDG (all p-values < .0005). Except all were visuospatial skills .05) .035). The fimbria most domains, including executive dysfunction (p = .011), language .006), visuomotor function .003), .001), .001). Conclusion current builds existing dysfunction. Longitudinal are required volumetric decline.